A facile approach to hydrophilic oxidized fullerenes and their derivatives as cytotoxic agents and supports for nanobiocatalytic systems.
Panagiota ZygouriKonstantinos SpyrouEfstratia MitsariMaría BarrioRoberto MacovezMichaela PatilaHaralambos StamatisIoannis I VerginadisAnastasia P VelalopoulouAngelos M EvangelouZili SideratouDimitrios GournisPetra RudolfPublished in: Scientific reports (2020)
A facile, environment-friendly, versatile and reproducible approach to the successful oxidation of fullerenes (oxC60) and the formation of highly hydrophilic fullerene derivatives is introduced. This synthesis relies on the widely known Staudenmaier's method for the oxidation of graphite, to produce both epoxy and hydroxy groups on the surface of fullerenes (C60) and thereby improve the solubility of the fullerene in polar solvents (e.g. water). The presence of epoxy groups allows for further functionalization via nucleophilic substitution reactions to generate new fullerene derivatives, which can potentially lead to a wealth of applications in the areas of medicine, biology, and composite materials. In order to justify the potential of oxidized C60 derivatives for bio-applications, we investigated their cytotoxicity in vitro as well as their utilization as support in biocatalysis applications, taking the immobilization of laccase for the decolorization of synthetic industrial dyes as a trial case.
Keyphrases
- solar cells
- liquid chromatography
- visible light
- structure activity relationship
- hydrogen peroxide
- ionic liquid
- quantum dots
- clinical trial
- highly efficient
- reduced graphene oxide
- heavy metals
- wastewater treatment
- study protocol
- phase iii
- metal organic framework
- mass spectrometry
- solid phase extraction
- phase ii
- human health
- risk assessment
- nitric oxide
- electron transfer
- simultaneous determination
- magnetic nanoparticles
- single molecule