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Determination of the Physicochemical Properties of Piroxicam.

Mustafa ÇelebierMerve NennİOzan KaplanEmrah AkgeyİkMustafa Sinan KaynakSelma Şahİn
Published in: Turkish journal of pharmaceutical sciences (2020)
In the literature, different Log P (3.1, 2.2, and 0.6) and pKa (6.3 and 4.8) values were reported for piroxicam. The Log P (1.58) and pKa (5.3 and 5.7) values obtained for piroxicam in our study were within the range of the literature values. All these results indicate that different experimental approaches used for the determination of physicochemical properties could provide different values. Although UV spectrophotometry is easy to apply, HPLC is a unique technique for simultaneous determination of pKa, Log D, and Log P values of compounds.
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