Confirmation of the Cardioprotective Effect of MitoGamide in the Diabetic Heart.
Min ParkTakanori NishimuraCarlos D Baeza-GarzaStuart T CaldwellPamela Boon Li PunHiran A PragTim YoungOlga SauchankaAngela LoganMarleen ForkinkAnja V GruszczykTracy A PrimeSabine ArndtAlba NaudiReinald PamplonaMelinda T CoughlanMitchel TateRebecca H RitchieFederico CaicciNina KaludercicFabio Di LisaRobin A J SmithRichard C HartleyMichael P MurphyThomas KriegPublished in: Cardiovascular drugs and therapy (2020)
Our work confirms that the Akita mouse model of diabetes replicates key clinical features of diabetic HFpEF, including cardiac and mitochondrial dysfunction. Furthermore, in this independent study, MitoGamide treatment improved diastolic function in Akita mice.