Oncogenic Akt-FOXO3 loop favors tumor-promoting modes and enhances oxidative damage-associated hepatocellular carcinogenesis.

Miao LuDaniel HartmannRickmer BrarenAayush GuptaBaocai WangYang WangCarolin MoglerZhangjun ChengThomas WirthHelmut FriessJörg KleeffNorbert HüserYoshiaki Sunami

Published in: BMC cancer (2019)

FOXO3 is a master regulator of ROS in a 'carrot and stick' manner; on one side avoiding cellular crisis while also supporting hepatocellular carcinogenesis. Clinically, we suggest analyzing FOXO3 activation status in patients with liver diseases, in addition to PI3K/Akt signaling. Personalized therapy of FOXO3 inhibition may be a reasonable, depending on the activation status of FOXO3.

Keyphrases

pi k akt
signaling pathway
transcription factor
cell proliferation
cell cycle arrest
dna damage
cell death
stem cells
replacement therapy