Long-Lasting Antibacterial PDMS Surfaces Constructed from Photocuring of End-Functionalized Polymers.

A challenge remains in the development of anti-infectious coatings for the inert surfaces of biomedical devices that are prone to bacterial colonization and biofilm formation. Here, we developed a facile photocuring method to construct functionalized polymeric coatings on inert PDMS surfaces. Using ATRP initiator bearing thymol group, hydrophilic DMAEMA and benzophenone-containing monomers were copolymerized to form polymers with end functional groups. An end-functionalized biocidal coating was then constructed on the inert PDMS surface in one step using a photocuring reaction. The functionalized PDMS surfaces show excellent antibacterial and antifouling properties, are capable of completely eradiating MRSA within approximately 6 hours, and effectively inhibit the growth of biofilms. In addition, it has good stability and long-lasting antibacterial activity in body fluid environments such as 0.9% saline and urine. According to bladder model experiments, the catheter's lifespan can be extended from approximately 7 to 35 days by inhibiting the growth and migration of bacteria along its inner surface. The photocuring technique is therefore very promising in terms of surface functionalization of inert biomedical devices in order to minimize the spread of infection. This article is protected by copyright. All rights reserved.