Interleukin-33 serum levels in postmenopausal women with osteoporosis.
Lia GinaldiMassimo De MartinisSalvatore SaittaMaria Maddalena SirufoCarmen MannucciMarco CasciaroFedra CiccarelliSebastiano GangemiPublished in: Scientific reports (2019)
There are many cytokines involved in the pathogenesis of osteoporosis. So far IL-33 involvement in osteoporotic patients has not yet been studied. IL-33 is a pro-inflammatory cytokine which mediates several immune functions; its involvement in a wide range of diseases, such as atopic dermatitis, asthma, and rheumatoid arthritis, is now emerging. In view of the crucial role of this cytokine in inflammation and bone remodeling, we measured IL-33 levels in the serum of postmenopausal women with osteoporosis. In 50 postmenopausal osteoporotic patients and 28 healthy postmenopausal control women, serum IL-33 levels were measured by enzyme linked immunosorbent assay. In both patients and controls the bone mineral density (BMD) was measured by double-energy X-ray absorptiometry (DXA). Vitamin D, calcium, alkaline phosphatase (ALP), parathyroid hormone (PTH) serum levels, as well as bone turnover markers, such as C-terminal telopeptide of type 1 collagen (CTX) and N-terminal propeptide of type 1 procollagen (P1NP) were also evaluated. In postmenopausal osteoporotic women IL-33 levels were significantly lower compared to healthy controls (3.53 ± 2.45 vs. 13.72 ± 5.39 pg/ml; P = 0.009) and positively correlated respectively with serum PTH (rho = 0.314; P = 0.026) and P1NP (rho = 0.373; P = 0.011) levels, while a statistically significant inverse correlation was observed between serum IL-33 and CTX levels (rho = -0.455; P = 0.002). Our results thus suggest that IL-33 represents an important bone-protecting cytokine which may be of therapeutic benefit in treating bone resorption.
Keyphrases
- bone mineral density
- postmenopausal women
- body composition
- end stage renal disease
- rheumatoid arthritis
- ejection fraction
- chronic kidney disease
- newly diagnosed
- prognostic factors
- magnetic resonance imaging
- metabolic syndrome
- peritoneal dialysis
- polycystic ovary syndrome
- escherichia coli
- chronic obstructive pulmonary disease
- magnetic resonance
- adipose tissue
- atopic dermatitis
- pregnant women
- skeletal muscle
- smooth muscle
- computed tomography
- systemic sclerosis
- ankylosing spondylitis