Neural correlates of early cognitive dysfunction in Parkinson's disease.

Rimona Sharon WeilJoel S WinstonLouise-Ann LeylandKaterina PappaRibeya B MahmoodHuw R MorrisGeraint Rees

Published in: Annals of clinical and translational neurology (2019)

Our findings suggest that functional connectivity is reduced between posterior and anterior hubs of the default mode network in Parkinson's patients who are likely to progress to worsening cognitive dysfunction. Our work implicates posterior default mode nodes and their connections as key brain regions in early stages of dementia in Parkinson's disease.

Keyphrases

functional connectivity
resting state
end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
peritoneal dialysis
mild cognitive impairment
multiple sclerosis
cognitive impairment
radiation therapy
rectal cancer
patient reported outcomes
white matter
early stage