TNF receptor-related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF-κB-inducing kinase-mediated hepatocyte transdifferentiation.

Yuto Shiode Takahiro KodamaSatoshi ShigenoKazuhiro MuraiSatoshi TanakaJustin Y NewbergJumpei KondoShogo KobayashiRyoko YamadaHayato HikitaRyotaro SakamoriHiroshi SuemizuTomohide TatsumiHidetoshi EguchiNancy A JenkinsNeal G CopelandTetsuo Takehara

Published in: Hepatology (Baltimore, Md.) (2022)

TRAF3 inactivation promotes ICC development through NIK-mediated hepatocyte transdifferentiation. The oncogenic TRAF3-NIK axis may be a potential therapeutic target for ICC.

Keyphrases

liver injury
signaling pathway
rheumatoid arthritis
oxidative stress
drug induced
pi k akt
cell proliferation
risk assessment
immune response
climate change
binding protein
inflammatory response