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Exploiting multivalency and cooperativity of gold nanoparticles for binding phosphatidylinositol (3,4,5)-trisphosphate at sub-nanomolar concentrations.

Flavio Della SalaElisa CeresaraFabrizio MicheliStefano FontanaLeonard J PrinsPaolo Scrimin
Published in: Organic & biomolecular chemistry (2023)
Cationic, monolayer-protected gold nanoparticles provide a multivalent charged surface and a hydrophobic monolayer that synergistically contribute to the binding of phosphatidylinositol (3,4,5)-trisphosphate, a relevant biomarker. The observed dissociation constant is in the picomolar region, providing the possibility of using these gold nanoparticles for the selective extraction of this molecule from biological fluids.
Keyphrases
  • gold nanoparticles
  • reduced graphene oxide
  • protein kinase
  • dna binding
  • binding protein
  • ionic liquid