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Evolutionary origin of germline pathogenic variants in human DNA mismatch repair genes.

Huijun LeiJiaheng LiBojin ZhaoSi Hoi KouFengxia XiaoTianhui ChenSan Ming Wang
Published in: Human genomics (2024)
Our study reveals that MMR PVs in modern humans were arisen within the recent human evolutionary history.
Keyphrases
  • endothelial cells
  • genome wide
  • induced pluripotent stem cells
  • copy number
  • single molecule
  • gene expression
  • oxidative stress
  • circulating tumor
  • dna damage
  • cell free
  • circulating tumor cells
  • genome wide identification