The autophagy-enhancing drug carbamazepine improves neuropathology and motor impairment in mouse models of Machado-Joseph disease.

Ana Vasconcelos-Ferreira Sara Carmo-SilvaJosé Miguel CodêssoPatrick SilvaAlberto Rolim Muro MartinezMarcondes Cavalcante de França Junior Clevio Nobrega Luis Pereira de Almeida

Published in: Neuropathology and applied neurobiology (2021)

Our data support the autophagy-enhancing activity of CBZ in the brain and suggest this pharmacological approach as a promising therapy for MJD and other polyglutamine disorders.

Keyphrases

cell death
endoplasmic reticulum stress
signaling pathway
mouse model
oxidative stress
resting state
white matter
big data
functional connectivity
emergency department
data analysis