Doppler sonography enhances rtPA-induced fibrinolysis in an in vitro clot model of spontaneous intracerebral hemorrhages.

Julia Masomi-BornwasserPhilipp WinterAxel NeulenSven R KantelhardtJochem KönigOliver KempskiFlorian RingelNaureen Keric

Published in: PloS one (2019)

TCD significantly enhances rtPA-induced lysis of blood clots, and the effect is amplified by using multiple probes. Our results indicate that bitemporal TCD insonation of hematomas could be a new and safe approach to enhance fibrinolysis of ICH´s treated with intralesional catheter and rtPA.

Keyphrases

high glucose
diabetic rats
drug induced
small molecule
oxidative stress
magnetic resonance imaging
computed tomography
blood flow
fluorescence imaging
photodynamic therapy
nucleic acid
stress induced