Ruthenium-catalyzed hydrogen isotope exchange of C(sp3)-H bonds directed by a sulfur atom.

Longhui GaoSerge PeratoSébastien Garcia-ArgoteCéline TaglangLuis Miguel Martínez-PrietoCéline CholletDavid-Alexandre BuissonVincent DauvoisPhilippe LesotBruno ChaudretBernard RousseauSophie FeuillastreGrégory Pieters

Published in: Chemical communications (Cambridge, England) (2018)

We present here the first example of C(sp3)-H activation directed by a sulfur atom. Based on this transformation catalyzed by Ru/C, we have developed a hydrogen isotope exchange reaction for the deuterium and tritium labelling of thioether substructures in complex molecules.

Keyphrases

room temperature
molecular dynamics
electron transfer
gas chromatography
mass spectrometry
high resolution
transition metal