Ruthenium-catalyzed hydrogen isotope exchange of C(sp3)-H bonds directed by a sulfur atom.
Longhui GaoSerge PeratoSébastien Garcia-ArgoteCéline TaglangLuis Miguel Martínez-PrietoCéline CholletDavid-Alexandre BuissonVincent DauvoisPhilippe LesotBruno ChaudretBernard RousseauSophie FeuillastreGrégory PietersPublished in: Chemical communications (Cambridge, England) (2018)
We present here the first example of C(sp3)-H activation directed by a sulfur atom. Based on this transformation catalyzed by Ru/C, we have developed a hydrogen isotope exchange reaction for the deuterium and tritium labelling of thioether substructures in complex molecules.