pH-Triggered nanoreactors as oxidative stress amplifiers for combating multidrug-resistant biofilms.
Lei HuangShangming JiangBo CaiGuobin WangZheng WangLin WangPublished in: Chemical communications (Cambridge, England) (2021)
Developing radical oxygen species (ROS)-generating nanoreactors as new "antibiotics" is a promising strategy for the treatment of multidrug-resistant (MDR) biofilm infections. Herein, we designed and fabricated silver nanoparticle-decorated calcium peroxide (CaO2) nanoreactors (CPA) for combating MDR biofilms. CPA could locally boost ROS production as oxidative stress amplifiers in a pH-triggered and self-catalytic manner in acidic biofilms, where H2O2 was released by the hydrolysis of CaO2 and sequentially catalyzed by Ag NPs in situ to generate O2˙-, thereby efficiently disrupting mature biofilms and killing bacteria.
Keyphrases
- multidrug resistant
- candida albicans
- oxidative stress
- drug resistant
- acinetobacter baumannii
- dna damage
- gram negative
- klebsiella pneumoniae
- biofilm formation
- reactive oxygen species
- cell death
- pseudomonas aeruginosa
- staphylococcus aureus
- highly efficient
- quantum dots
- ischemia reperfusion injury
- ionic liquid
- room temperature
- gold nanoparticles
- visible light
- induced apoptosis
- crystal structure