Improved Tumor Infiltration and Immunomodulation for Tumor Therapy: A Pathway Based on Tetrahedral Framework Nucleic Acids Coupled Bacterial Nanocells.
Yuxi ZhanYuxin ZhangChenchen MaoJiajie LiYuxuan ZhaoYe ChenZhiqiang LiuYunfeng LinPublished in: Nano letters (2022)
Growing evidence indicates that the tumor microenvironment (TME) can be combined with other therapeutic modalities, including cytotoxic chemotherapy and targeted therapies, to produce unanticipated results in oncology treatment. Here, we proposed a novel bacterial nanomaterial capable of targeting peritumoral biofilm and modulating TME. It was based on tetrahedral framework nucleic acids (T) that were chemically attached to aptamer AS1411 and 5-fluorouracil (AT5). Additionally, the oral pathogenic bacterium Streptococcus mutans (S.m) was employed as a biocarrier for synergetic biofilm targeting and immunomodulation. In this article, the effect of AT5-coupled S.m-derived nanocells (S.m-AT5) was investigated in vitro and in vivo . Due to bacteria aggregation in the tumor-specific biofilm, these nanocells released greater medication concentrations. Furthermore, they exerted an immunomodulatory effect by stimulating the maturation of dendritic cells (DCs) and regulation of T cells. This chemo-immunostimulation combination has a powerful antitumor impact. It may also be an advanced approach for boosting the survival rate of cancer patients.
Keyphrases
- candida albicans
- biofilm formation
- pseudomonas aeruginosa
- staphylococcus aureus
- dendritic cells
- cancer therapy
- immune response
- gold nanoparticles
- healthcare
- emergency department
- escherichia coli
- locally advanced
- drug delivery
- palliative care
- cystic fibrosis
- combination therapy
- squamous cell carcinoma
- mass spectrometry
- photodynamic therapy
- regulatory t cells
- high resolution
- rectal cancer
- cell therapy
- label free
- high speed