PAK Kinase Inhibition Has Therapeutic Activity in Novel Preclinical Models of Adult T-Cell Leukemia/Lymphoma.

Elaine Y ChungYun MaiUrvi A ShahYongqiang WeiElise IshidaKeisuke KataokaXiaoxin RenKith PradhanBoris A BartholdyXiaolei WeiYiyu ZouJinghang ZhangSeishi OgawaUlrich SteidlXingxing ZangAmit VermaMurali JanakiramB Hilda Ye

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

PAK2, a gene frequently amplified in ATLL, facilitates CADM1-mediated stromal interaction and promotes survival of ATLL cells. Taken together, PAK inhibition may hold significant promise as a targeted therapy for aggressive ATLLs.

Keyphrases

bone marrow
induced apoptosis
cell cycle arrest
acute myeloid leukemia
diffuse large b cell lymphoma
copy number
genome wide
cancer therapy
endoplasmic reticulum stress
big data
gene expression
oxidative stress
cell therapy
dna methylation
transcription factor
drug delivery
artificial intelligence