Identification of the E2F1-RAD51AP1 axis as a key factor in MGMT-methylated GBM TMZ resistance.

Junhu ZhouFei TongJixing ZhaoXiaoteng CuiYunfei WangGuangxiu WangChunsheng KangXiaomin Liu Qixue Wang

Published in: Cancer biology & medicine (2023)

Our results suggest that E2F1 is a key transcription factor in EGFRvIII-positive glioma cells and quickly responds to TMZ treatment. RAD51AP1 was shown to be upregulated by E2F1 for DNA double strand break repair. Targeting RAD51AP1 could facilitate achieving an ideal therapeutic effect in MGMT-methylated GBM cells.

Keyphrases

transcription factor
dna repair
dna damage
dna binding
induced apoptosis
cell cycle arrest
single molecule
cell free
circulating tumor
cancer therapy
genome wide identification
cell death
oxidative stress
combination therapy
nucleic acid
signaling pathway
replacement therapy