Airway microbiome composition correlates with lung function and arterial stiffness in an age-dependent manner.
Shuen Yee LeeMicheál Mac AogáinKai Deng FamKar Ling ChiaNur A'tikah Binte Mohamed AliMargaret M C YapEric P H YapSanjay Haresh ChotirmallChin Leong LimPublished in: PloS one (2019)
Ageing is associated with increased Firmicutes and decreased Proteobacteria representation in the airway microbiome among a healthy Asian cohort. The diversity and composition of the airway microbiome is independently associated with lung function and arterial stiffness in the young and elderly groups respectively. This suggests differential microbial associations with these phenotypes at specific stages of life with potential prognostic implications.