Panobinostat inhibits the proliferation of CD34+ CD38- cells under stimulation of hematopoietic growth factors on AGM-S3 cells in juvenile myelomonocytic leukemia.

Takashi KurataKazuyuki MatsudaKoichi Hirabayashi Tomonari ShigemuraKazuo SakashitaTatsutoshi NakahataKenichi Koike

Published in: Pediatric blood & cancer (2018)

These results demonstrate that panobinostat directly suppresses the growth of JMML CD34+ cells, in particular CD34+ CD38- cells, regardless of the genetic abnormality type, suggesting that it is a useful antileukemic drug to target JMML stem cells at a pretransplant stage.

Keyphrases

induced apoptosis
cell cycle arrest
stem cells
signaling pathway
emergency department
mesenchymal stem cells
acute myeloid leukemia
dna methylation
pi k akt
genome wide