Update on Osteosarcoma.
Rebekah BelaynehMitchell S FourmanSumail BhogalKurt R WeissPublished in: Current oncology reports (2021)
The advent of neoadjuvant and adjuvant chemotherapy has markedly improved the disease-free recurrence and overall survival of OSA. However, treatment efficacy has been stagnant since the 1980s. This plateau has prompted preclinical and clinical research into in precision surgery, inhaled chemotherapy to increase pulmonary drug concentration without systemic side effects, and novel immunomodulators intended to block molecular pathways associated with OSA proliferation and metastasis. With the advent of novel surgical techniques and new forms and vectors for chemotherapy, it is hoped that OSA treatment outcomes will exceed their currently sustained plateau in the near future.
Keyphrases
- obstructive sleep apnea
- locally advanced
- positive airway pressure
- rectal cancer
- minimally invasive
- free survival
- squamous cell carcinoma
- coronary artery bypass
- radiation therapy
- pulmonary hypertension
- signaling pathway
- sleep apnea
- emergency department
- drug induced
- current status
- single molecule
- surgical site infection
- chemotherapy induced
- percutaneous coronary intervention
- replacement therapy
- gene therapy