Association of TLR variants with susceptibility to Plasmodium vivax malaria and parasitemia in the Amazon region of Brazil.

Allyson Guimarães CostaRajendranath RamasawmyHiochelson Najibe Santos IbiapinaVanderson Souza SampaioLilyane Amorim XábregasLarissa Wanderley BrasilAndréa Monteiro TarragôAnne Cristine Gomes AlmeidaAndrea KuehnSheila Vitor-SilvaGisely Cardoso MeloAndré Machado SiqueiraWuelton Marcelo MonteiroMarcus Vinicius Guimarães LacerdaAdriana Malheiro

Published in: PloS one (2017)

Variants of TLRs may predispose individuals to infection by P. vivax. The TLR5 R392StopCodon and TLR9 -1486C/T variants are associated with susceptibility to Pv-malaria. Furthermore, the TLR9 variant -1237C/C correlates with high parasitemia.

Keyphrases

toll like receptor
inflammatory response
immune response
copy number
plasmodium falciparum
nuclear factor
gene expression