A pan-cancer analysis of driver gene mutations, DNA methylation and gene expressions reveals that chromatin remodeling is a major mechanism inducing global changes in cancer epigenomes.

Ahrim YounKyung In KimRaul RabadanBenjamin TyckoYufeng ShenShuang Wang

Published in: BMC medical genomics (2018)

This finding suggests a pivotal role for genetically driven changes in chromatin remodeling in shaping DNA methylation and gene expression patterns during tumor development.

Keyphrases

gene expression
dna methylation
genome wide
papillary thyroid
squamous cell
dna damage
copy number
transcription factor
lymph node metastasis
squamous cell carcinoma
genome wide identification