PAI-1 gain-of-function genotype, factors increasing PAI-1 levels, and airway obstruction: The GALA II Cohort.
M G SherenianS H ChoA LevinJ-Y MinS S OhD HuJ GalanterS SenS HuntsmanC EngJ R Rodriguez-SantanaD SerebriskyP C AvilaR KalhanL J SmithL N BorrellM A SeiboldL Keoki WilliamsE G BurchardRajesh KumarPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2017)
The decrease in the FEV1 /FVC ratio associated with the risk genotype was modified by asthma status. The genotype increased the odds of airway obstruction by 75% within asthmatics only. As exposures known to increase PAI-1 levels did not mitigate this association, PAI-1 may contribute to airway obstruction in the context of chronic asthmatic airway inflammation.