Mesenchymal stem cells-derived small extracellular vesicles alleviate diabetic retinopathy by delivering NEDD4.
Fengtian SunYuntong SunJunyan ZhuXiaoling WangCheng JiJiahui ZhangShenyuan ChenYifan YuWenrong XuWenrong XuPublished in: Stem cell research & therapy (2022)
Our findings indicated that MSC-sEV ameliorated DR through NEDD4-induced regulation on PTEN/AKT/NRF2 signaling pathway, thus revealing the efficiency and mechanism of MSC-sEV-based retinal protection and providing new insights into the treatment of DR.
Keyphrases
- diabetic retinopathy
- signaling pathway
- mesenchymal stem cells
- optical coherence tomography
- pi k akt
- cell proliferation
- editorial comment
- oxidative stress
- high glucose
- diabetic rats
- epithelial mesenchymal transition
- umbilical cord
- bone marrow
- induced apoptosis
- drug induced
- combination therapy
- endoplasmic reticulum stress