Von Willebrand factor propeptide and pathophysiological mechanisms in European and Iranian patients with type 3 von Willebrand disease enrolled in the 3WINTERS-IPS study.
Maria Teresa PagliariFrits R RosendaalMinoo AhmadinejadZahra BadieeMohammad-Reza BaghaipourLuciano BaroncianiOlga Benítez HidalgoImre BodóUlrich BuddeGiancarlo CastamanPeyman EshghiJenny GoudemandMehran KarimiBijan KeikhaeiRiitta LassilaFrank W G LeebeekMaria Fernanda Lopez FernandezPier Mannuccio MannucciRenato MarinoJohannes OldenburgIan PeakeCristina SantoroReinhard SchneppenheimAndreas TiedeGholamreza ToogehAlberto TosettoMarc TrossaertHamideh YadegariEva M K ZetterbergFlora PeyvandiAugusto B FedericiJeroen C J EikenboomPublished in: Journal of thrombosis and haemostasis : JTH (2022)
An increased VWFpp/VWF:Ag ratio is indicative of missense variants, whereas FVIII:C/VWF:Ag ratio does not discriminate missense from null alleles. The VWFpp level was not associated with the severity of bleeding phenotype.