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Steroidal alkaloid with unprecedented triheterocyclic architecture.

Zhong-Shun ZhouYun-Li ZhaoBin-Yuan HuBei WangYa-Ping LiuYan-Yan ZhuYing-Jie HeZhao-Jie WangZhi DaiLi-Xing ZhaoXiao-Dong Luo
Published in: Chemical communications (Cambridge, England) (2022)
Veratrazine A (1), a steroidal alkaloid with a unique 6/5/5 triheterocyclic scaffold as the side chain, was isolated from Veratrum stenophyllum , and its structure was established via spectroscopic analyses and X-ray diffraction. A plausible biosynthetic pathway for 1 is proposed. Bioassy exhibits moderate anti-inflammatory activities in vitro and in vivo .
Keyphrases
  • anti inflammatory drugs
  • anti inflammatory
  • electron microscopy
  • molecular docking
  • high resolution
  • high intensity
  • dual energy
  • tissue engineering
  • crystal structure
  • magnetic resonance imaging