Protein identification for stroke progression via Mendelian Randomization in Million Veteran Program and UK Biobank.
Andrew R ElmoreNimish AdhikariApril E HartleyHugo Javier AparicioDaniel C PosnerGibran HemaniKate TillingTom R GauntPeter W F WilsonJ P CasasJohn Michael GazianoGeorge Davey SmithLavinia PaternosterKelly ChoGina M PelosoPublished in: medRxiv : the preprint server for health sciences (2024)
We found evidence that two proteins with little effect on incident stroke appear to influence subsequent MACE after incident AIS. These associations suggest that inflammation is a contributing factor to subsequent MACE outcomes after incident AIS and highlights potential novel targets.