Reclassification of a spindle cell sarcoma after identification of a TFG-ROS1 fusion: A case demonstrating the clinical benefit of next-generation sequencing in sarcoma.
John J LimEleanor Y ChenStephanie K SchaubMichael J WagnerPublished in: Molecular genetics & genomic medicine (2024)
We discuss the role of NGS as well as its potential benefit in patients with unresectable, ALK-negative metastatic disease. Considering this case and previous literature, we support the use of NGS for patients requiring systemic treatment.
Keyphrases
- end stage renal disease
- ejection fraction
- systematic review
- squamous cell carcinoma
- chronic kidney disease
- small cell lung cancer
- peritoneal dialysis
- prognostic factors
- dna damage
- cell therapy
- stem cells
- cell death
- radiation therapy
- single cell
- gene expression
- patient reported outcomes
- locally advanced
- oxidative stress
- copy number
- dna methylation
- reactive oxygen species
- genome wide
- patient reported
- tyrosine kinase
- rectal cancer