Using negative control outcomes to assess the comparability of treatment groups among women with osteoporosis in the United States.

Leah J McGrathLeslie SpanglerJeffrey R CurtisVera EhrensteinHenrik T SørensenBradley SaulSara N LevintowDiane ReamsBrian D BradburyM Alan Brookhart

Published in: Pharmacoepidemiology and drug safety (2020)

Caution is warranted when comparing injectable vs oral osteoporosis medications, given the potential for unmeasured confounding. Evaluating negative control outcomes could be a standard validity check prior to conducting comparative studies.

Keyphrases

postmenopausal women
bone mineral density
type diabetes
metabolic syndrome
hyaluronic acid
glycemic control
combination therapy
climate change
risk assessment
body composition
weight loss
smoking cessation