Escherichia coli-derived outer-membrane vesicles induce immune activation and progression of cirrhosis in mice and humans.

Kazuki NatsuiAtsunori TsuchiyaRisa ImamiyaMayuko Osada-OkaYui IshiiYohei KosekiNobutaka TakedaKei TomiyoshiFusako YamazakiYuki YoshidaRiuko OhashiYiwei LingKoji UedaNobuko MoritokiKazuhiro SatoTakahiro NakajimaYoshinori HasegawaShujiro OkudaShinsuke ShibataShuji Terai

Published in: Liver international : official journal of the International Association for the Study of the Liver (2023)

In conclusion, OMVs induce inflammation, fibrosis and suppression of albumin production, affecting the pathogenesis of cirrhosis. We believe that our study paves the way for the future prevention and treatment of cirrhosis.

Keyphrases

escherichia coli
oxidative stress
high fat diet induced
type diabetes
metabolic syndrome
combination therapy
insulin resistance