Non-coding RNA therapeutics in the treatment of heart failure.

Aleksandra PaterekMarta Załęska-KocięckaMateusz SurzykiewiczZuzanna WojdyńskaPrzemysław LeszekMichał Mączewski

Published in: European heart journal. Cardiovascular pharmacotherapy (2024)

Non-coding RNA (ncRNA) therapeutics can target either ncRNAs or conventional messenger RNA, offering both superior pharmacokinetics and selectivity to conventional therapies and addressing new, previously unexplored pathways. Although no ncRNA has yet been approved for the treatment of heart failure, in this review we present five most promising pathways and agents that either are in human clinical trials or offer great promise in the near future.

Keyphrases

heart failure
clinical trial
endothelial cells
left ventricular
atrial fibrillation
nucleic acid
acute heart failure
big data
machine learning
replacement therapy
current status
induced pluripotent stem cells
smoking cessation