CpG islands in MyD88 and ASC/PYCARD/TMS1 promoter regions are differentially methylated in head and neck squamous cell carcinoma and primary lung squamous cell carcinoma.
Maja ŠutićJurica BaranašićLana Kovač BilićMario BilićAntonija JakovčevićLuka BrčićSven SeiwerthMarko JakopovićMiroslav SamaržijaUlrich ZechnerJelena KneževićPublished in: Diagnostic pathology (2021)
Results of the present study indicate that there is a significant difference in the methylation status of tested genes between primary HNSCC and LuSCC. However, to prove this approach as a useful tool for distinguishing second primary LuSCC from HNSCC metastasis, it would be necessary to include a larger number of samples, and most importantly, metastatic samples.