MRI and flortaucipir relationships in Alzheimer's phenotypes are heterogeneous.
Keith Anthony JosephsNirubol TosakulwongJonathan Graff-RadfordStephen D WeigandMarina BuciucMary M MachuldaDavid T JonesChristopher G SchwarzMatthew L SenjemNilufer Ertekin-TanerKejal KantarciBradley F BoeveDavid S KnopmanClifford R JackRonald C PetersenVal J LoweJennifer L WhitwellPublished in: Annals of clinical and translational neurology (2020)
MRI volumetry versus flortaucipir PET relationships differ across Alzheimer's clinical phenotypes, and also within phenotype across age decades. This suggests that there is potential risk of masked effects by not accounting for genarian in participants with beta-amyloid and tau-positive biomarker defined Alzheimer's disease.