Efficacy and safety of calcium channel blockers in preventing cardiac siderosis in thalassemia patients: An updated meta-analysis with trial sequential analysis.

Youssef SolimanAhmed AbdelazizAdel MouffokesBasma E AmerYomna Mohamed GoudyOmar Ahmed AbdelwahabMarwa M BadawyRehab Adel DiabAsmaa Elsharkawy

Published in: European journal of haematology (2023)

Our meta-analysis found that amlodipine significantly increases cardiac T2* and decreases MIC, hence decreasing the incidence of cardiomyopathy-related iron overload in thalassemia patients.

Keyphrases

systematic review
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
heart failure
peritoneal dialysis
meta analyses
study protocol
blood pressure
iron deficiency
data analysis