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The influence of trinucleotide repeats in the androgen receptor gene on androgen-related traits and diseases.

Takayoshi SasakoYann IlboudoKevin Y H LiangYiheng ChenSatoshi YoshijiJohn Brent Richards
Published in: The Journal of clinical endocrinology and metabolism (2024)
In this large-scale study, we found that longer CAG and GGC repeats in the AR gene influence androgen resistance, elevate circulating testosterone level via a feedback loop and play a role in some androgen-targeted tissues. Generally, however, circulating testosterone level is a more important determinant of androgen action in males than repeat lengths.
Keyphrases
  • genome wide
  • copy number
  • replacement therapy
  • genome wide identification
  • transcription factor
  • cancer therapy
  • dna methylation
  • drug delivery
  • smoking cessation
  • genome wide analysis
  • drug induced