Working memory during spontaneous migraine attacks: an fMRI study.
Amparo Ruiz-TaglePatricia FiguereidoJoana PintoPedro VilelaIsabel Pavão MartinsRaquel Gil-GouveiaPublished in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2023)
Migraine patients exhibited greater activation of the left frontal pole and orbitofrontal cortex while executing a verbal working memory task during a spontaneous migraine attack when compared to the interictal state. Given the association of these regions with pain processing and inhibitory control, these findings suggest that patients recruit inhibitory areas to accomplish the cognitive task during migraine attacks, a neural signature of their cognitive difficulties.