The DRD2 antagonist haloperidol mediates autophagy-induced ferroptosis to increase temozolomide sensitivity by promoting endoplasmic reticulum stress in glioblastoma.
Linyong ShiHanning ChenKunxiang ChenChengzong ZhongChong SongYifeng HuangTong WangLei ChenChiyang LiAnnie HuangHong LiYuntao LuPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Our results provide experimental evidence for repurposing HP as an effective adjunct therapy to inhibit adaptive TMZ resistance in order to enhance the efficacy of chemoradiotherapy in GBM, a strategy that may have broad prospects for clinical application.