Maternal Multivitamin Intake, Plasma Folate and Vitamin B12 Levels and Autism Spectrum Disorder Risk in Offspring.

Ramkripa RaghavanAnne W RileyHeather VolkDeanna CarusoLynn HironakaLaura SicesXiumei HongGuoying WangYuelong JiMartha BrucatoAnastacia WahlTom StiversColleen PearsonBarry ZuckermanElizabeth A StuartRebecca LandaM Daniele FallinXiaobin Wang

Published in: Paediatric and perinatal epidemiology (2017)

There was a 'U shaped' relationship between maternal multivitamin supplementation frequency and ASD risk. Extremely high maternal plasma folate and B12 levels at birth were associated with ASD risk. This hypothesis-generating study does not question the importance of consuming adequate folic acid and vitamin B12 during pregnancy; rather, raises new questions about the impact of extremely elevated levels of plasma folate and B12 exposure in-utero on early brain development.

Keyphrases

autism spectrum disorder
pregnancy outcomes
attention deficit hyperactivity disorder
birth weight
intellectual disability
type diabetes
pregnant women
high fat diet
skeletal muscle
multiple sclerosis
resting state
brain injury
functional connectivity
subarachnoid hemorrhage