Influenza-specific IgG1+ memory B-cell numbers increase upon booster vaccination in healthy adults but not in patients with predominantly antibody deficiency.
Gemma E HartleyEmily S J EdwardsJulian J BoscoSamar OjaimiRobert G StirlingPaul U CameronKatie Louise FlanaganMagdalena PlebanskiPhilip Mark HogarthRobyn Elizabeth O'HehirMenno C van ZelmPublished in: Clinical & translational immunology (2020)
We have successfully identified AM15-specific Bmem cells in healthy controls and PAD patients. The presence of antigen-specific Bmem cells could offer an additional diagnostic tool to aid in the clinical diagnosis of PAD. Furthermore, alterations in the number or immunophenotype of HA-specific Bmem cells post-booster vaccination could assist in the evaluation of immune responses in individuals receiving IgRT.