Oleanolic Acid Exerts Osteoprotective Effects and Modulates Vitamin D Metabolism.
Sisi CaoXiao-Li DongMing-Xian HoWen-Xuan YuKa-Chun WongXin-Sheng YaoMan-Sau WongPublished in: Nutrients (2018)
Oleanolic acid (OA) is a triterpenoid with reported bone anti-resorption activities. The present study aimed to characterize its bone protective effects in vivo and to study its effects on vitamin D metabolism, both in vivo and in vitro. OA significantly increased bone mineral density, improved micro-architectural properties, reduced urinary Ca excretion, increased 1,25(OH)₂D₃ and renal CYP27B1 mRNA expression in mature C57BL/6 ovariectomised (OVX) mice. OA also improved bone properties, Ca balance, and exerted modulatory effects on renal CYP27B1 and CYP24A1 expressions in aged normal female Sprague-Dawley rats. In addition, OA significantly increased renal CYP27B1 mRNA and promoter activity, and suppressed CYP24A1 mRNA and protein expressions in human proximal tubule HKC-8 cells. OA exerted bone protective effects in mature OVX mice and aged female rats. This action on bone might be, at least in part, associated with its effects on Ca and vitamin D metabolism. The present findings suggest that OA is a potential drug candidate for the management of postmenopausal osteoporosis.
Keyphrases
- bone mineral density
- postmenopausal women
- body composition
- knee osteoarthritis
- bone loss
- binding protein
- emergency department
- gene expression
- endothelial cells
- dna methylation
- transcription factor
- type diabetes
- soft tissue
- oxidative stress
- cell proliferation
- climate change
- endoplasmic reticulum stress
- human health
- wild type
- adverse drug
- pi k akt
- amino acid