Small molecule-driven SIRT3-autophagy-mediated NLRP3 inflammasome inhibition ameliorates inflammatory crosstalk between macrophages and adipocytes.

Tian ZhangZhujun FangKe-Gang LinghuJingxin LiuLishe GanLi-Gen Lin

Published in: British journal of pharmacology (2020)

AEDC attenuated the inflammatory crosstalk between macrophages and adipocytes through SIRT3-autophagy-mediated NLRP3 inflammasome inhibition, which might used for the treatment of adipose tissue inflammation-related metabolic disorders.

Keyphrases

nlrp inflammasome
oxidative stress
adipose tissue
small molecule
ischemia reperfusion injury
cell death
insulin resistance
high fat diet
endoplasmic reticulum stress
signaling pathway
mouse model
type diabetes
protein protein
high fat diet induced
replacement therapy