Efficacy and safety of apixaban vs warfarin in patients with atrial fibrillation and prior bioprosthetic valve replacement or valve repair: Insights from the ARISTOTLE trial.
Patricia O GuimarãesSean D PokorneyRenato Deláscio LopesDaniel M WojdylaBernard J GershAnna GiczewskaAnthony CarnicelliBasil S LewisMichael HannaLars WallentinDragos VinereanuJohn H AlexanderChristopher B GrangerPublished in: Clinical cardiology (2019)
In patients with AF and a history of BPV replacement or repair, the safety and efficacy of apixaban compared with warfarin was consistent with results from ARISTOTLE. These data suggest that apixaban may be reasonable for patients with BPVs or prior valve repair, though future larger randomized trials are needed. CLINICALTRIALS.GOV: NCT00412984.
Keyphrases
- atrial fibrillation
- aortic valve
- mitral valve
- venous thromboembolism
- aortic stenosis
- direct oral anticoagulants
- transcatheter aortic valve replacement
- aortic valve replacement
- oral anticoagulants
- transcatheter aortic valve implantation
- heart failure
- clinical trial
- left ventricular
- study protocol
- coronary artery disease
- phase iii
- big data
- machine learning
- ejection fraction
- double blind