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ATF4-mediated microRNA-145/HDAC4/p53 axis affects resistance of colorectal cancer cells to 5-fluorouracil by regulating autophagy.

Lin ZhaoHong ChenQingYi ZhangJin MaHao HuLu Xu
Published in: Cancer chemotherapy and pharmacology (2022)
In conclusion, ATF4-mediated miR-145 inhibition accelerated autophagy of CRC cells and boosted their resistance to 5-FU via the HDAC4/p53 axis.
Keyphrases
  • endoplasmic reticulum stress
  • induced apoptosis
  • cell death
  • cell cycle arrest
  • signaling pathway
  • cell proliferation
  • oxidative stress
  • transcription factor
  • histone deacetylase
  • long non coding rna
  • pi k akt