Multigene Panel Testing in Individuals With Hepatocellular Carcinoma Identifies Pathogenic Germline Variants.
Anya MezinaNeil PhilipsZoe BogusNoam ErezRui XiaoRuoming FanKim M OlthoffRajender K ReddyN Jewel SamadderSarah M NielsenKathryn E HatchellEdward D EsplinAnil K RustgiBryson W KatonaMaarouf A HoteitKatherine L NathansonKirk J WangensteenPublished in: JCO precision oncology (2021)
P/LP germline variants in cancer predisposition genes were detected in 11%-14% of patients with HCC. Inherited genetics should not be overlooked in HCC as there are important implications for precision treatment, future risk of cancers, and familial cancer risk.