Multigene Panel Testing in Individuals With Hepatocellular Carcinoma Identifies Pathogenic Germline Variants.

Anya MezinaNeil PhilipsZoe BogusNoam ErezRui XiaoRuoming FanKim M OlthoffRajender K Reddy N Jewel SamadderSarah M NielsenKathryn E Hatchell Edward D EsplinAnil K RustgiBryson W KatonaMaarouf A HoteitKatherine L Nathanson Kirk J Wangensteen

Published in: JCO precision oncology (2021)

P/LP germline variants in cancer predisposition genes were detected in 11%-14% of patients with HCC. Inherited genetics should not be overlooked in HCC as there are important implications for precision treatment, future risk of cancers, and familial cancer risk.

Keyphrases

copy number
genome wide
dna repair
papillary thyroid
early onset
squamous cell
current status
dna methylation
childhood cancer
oxidative stress
genome wide analysis