FBXW7 regulates the sensitivity of imatinib in gastrointestinal stromal tumors by targeting MCL1.

Xiyu WuMasaaki IwatsukiMasakazu TakakiTakuro SaitoTsutomu HayashiMasato KondoYoshiharu SakaiNaoto GotohdaEiji TanakaToshirou NishidaHideo Baba

Published in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2023)

FBXW7 regulates imatinib sensitivity by inhibiting MCL1 to enhance imatinib-induced apoptosis in GIST, and predicts efficacy of imatinib treatment in high-risk GIST patients treated with imatinib.

Keyphrases

chronic myeloid leukemia
induced apoptosis
signaling pathway
endoplasmic reticulum stress
oxidative stress