Immunohistochemical analysis of protective effects of maternal fingolimod on the placenta and fetal lung and brain in chorioamnionitis-induced preterm birth rat model.
And YavuzMekin SezikSerenat Eris YalcinHalil AşçiOzlem OzmenPublished in: Immunopharmacology and immunotoxicology (2020)
The findings of the present study confirm the neuroprotective effects of antenatally administered fingolimod, which also significantly improved preterm fetal lung injury and placental inflammation in LPS-exposed preterm pregnancies by possible antiapoptotic and anti-inflammatory effects.
Keyphrases
- preterm birth
- gestational age
- low birth weight
- multiple sclerosis
- birth weight
- oxidative stress
- white matter
- cerebral ischemia
- high glucose
- resting state
- diabetic rats
- inflammatory response
- functional connectivity
- drug induced
- anti inflammatory
- pregnancy outcomes
- body mass index
- pregnant women
- subarachnoid hemorrhage