The usefulness of lymphoid enhancer-binding factor 1 and androgen receptor in diagnosing solid pseudopapillary neoplasm of the pancreas on cytopathology.

Kelsey E McHugh Edward B StelowGrant P HarrisonMaria Luisa C Policarpio-Nicolas

Published in: Cancer cytopathology (2019)

LEF1 for SPN on cytology material was found to demonstrate a sensitivity of 94.7% and a specificity of 87%. Although AR was found to have a specificity of 100%, its sensitivity was lower (25%). LEF1 could be a valuable immunostain on cytology cell block material for the diagnosis of SPN. However, the same may not hold true for AR.

Keyphrases

fine needle aspiration
ultrasound guided
high grade
low grade
binding protein
single cell
structural basis
cell therapy
transcription factor
dna binding
bone marrow