Tangshen formula improves diabetic nephropathy in STZ-induced diabetes rats fed with hyper-methionine by regulating the methylation status of kidney.
Yongwei JiangGuoXiong DengChengyin LiuHan TangJing ZhengXiaomu KongMeimei ZhaoYi LiuPeng GaoTianbao LiHailing ZhaoYongtong CaoPing LiLiang MaPublished in: Clinical epigenetics (2024)
While HM exacerbates DN through altered methylation patterns at specific CpG sites, TSF holds promise as a viable treatment for DN by restoring abnormal methylation levels. The identification of specific genes provides valuable insights into the underlying mechanisms of DN pathogenesis and offers potential therapeutic targets for further investigation.
Keyphrases
- genome wide
- diabetic nephropathy
- dna methylation
- diabetic rats
- bioinformatics analysis
- type diabetes
- cardiovascular disease
- high glucose
- oxidative stress
- gene expression
- glycemic control
- adipose tissue
- machine learning
- drug induced
- endothelial cells
- transcription factor
- replacement therapy
- insulin resistance
- genome wide analysis
- artificial intelligence