Zn2+-Dependent peptide nucleic acid-based artificial ribonucleases with unprecedented efficiency and specificity.

Olivia LuigePartha Pratim BoseRouven StulzPeter SteunenbergOmar BrunShalini AnderssonMerita MurtolaRoger Strömberg

Published in: Chemical communications (Cambridge, England) (2021)

We present Zn2+-dependent dimethyl-dipyridophenazine PNA conjugates as efficient RNA cleaving artificial enzymes. These PNAzymes display site-specific RNA cleavage with 10 minute half-lives and cleave clinically relevant RNA models.

Keyphrases

nucleic acid
heavy metals
cancer therapy
risk assessment
structural basis