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Development of Murine Systemic Lupus Erythematosus in the Absence of BAFF.

William StohlNing YuSamantha ChalmersChaim PuttermanChaim O Jacob
Published in: Arthritis & rheumatology (Hoboken, N.J.) (2019)
The role of BAFF in the development of SLE-like disease may be dispensable as long as B cell survival is preserved via a BAFF-independent pathway. This may help explain the limited and variable clinical success with BAFF antagonists in human SLE. Thus, NZM.Baff-/- .Bcl2Tg mice may serve as a powerful murine model for the study of BAFF-independent SLE.
Keyphrases
  • systemic lupus erythematosus
  • disease activity
  • endothelial cells
  • rheumatoid arthritis
  • adipose tissue
  • insulin resistance
  • wild type